|
|
 |
|
|
faculty profile |
|
|
| Dr. Ann Loraine |
| Associate Professor |
 |
Department: Bioinformatics |
|
Office: NCRC: 203 Oak Ave, Kannapolis On Campus: 242 Cameron |
|
Office Hours: By appointment |
|
Email: aloraine@uncc.edu |
|
Phone: NCRC Office: 704-250-5750 |
|
Personal Homepage |
|
|
|
 |
|
|
|
|
|
Research Description:
Alternative splicing permits a single gene to generate multiple distinct mRNA products, each of which may encode proteins with distinct but related functions. The lab is working on developing computational and experimental approaches for studying how alternative affects gene function, paying particular attention its role in stress responses and disease. Complementary to this work, we are developing highly-interactive genome display software useful for inspecting splicing patterns and exploring genome-scale data sets. We are also developing strategies for data distribution aimed at supporting computational biology applications and large-scale mining of expression data. |
|
|
Recent Publications:
Srinivasasainagendra V, Page G, Mehta T, Coulibaly I, Loraine AE. CressExpress: A tool for large-scale mining of expression data from Arabidopsis thaliana. Plant Physiology. in press
French CT, Lao P, Loraine AE, Matthews BT, Yu H, Dybvig K. Large-Scale Transposon Mutagenesis of Mycoplasma pulmonis. Mol Microbiol. 2008 Apr 28 [Epub ahead of print].
Shriner D, Baye TM, Padilla MA, Zhang S, Vaughan LK, Loraine AE. Commonality of functional annotation: a method for prioritization of candidate genes from genome-wide linkage studies. Nucleic Acids Res. 2008 Mar;36(4):e26. Epub 2008 Feb 7.
Ye J, Cui X, Loraine A, Bynum K, Kim NC, White G, De Luca M, Garfinkel MD, Lu X, Ruden DM. Methods for nutrigenomics and longevity studies in Drosophila: effects of diets high in sucrose, palmitic acid, soy, or beef. Methods Mol Biol. 2007;371:111-41. Review.
Wei H, Persson S, Mehta T, Srinivasasainagendra V, Chen L, Page GP, Somerville C, Loraine A. Transcriptional coordination of the metabolic network in Arabidopsis. Plant Physiol. 2006 Oct;142(2):762-74. Epub 2006 Aug 18.
Cui X, Loraine A. Global Correlation Analysis Between Redundant Probe Sets Using a Large Collection of Arabidopsis ATH1 Expression Profiling Data. Proc. LSS Comp. Systems Bioinf. 2006, p. 223-226.
Shapero MH, Zhang J, Loraine A, Liu W, Di X, Liu G, Jones KW. MARA: a novel approach for highly multiplexed locus-specific SNP genotyping using high-density DNA oligonucleotide arrays. Nucleic Acids Res. 2004 Dec 15;32(22):e181.
Cline MS, Shigeta R, Wheeler RL, Siani-Rose MA, Kulp D, Loraine AE. The effects of alternative splicing on transmembrane proteins in the mouse genome. Pac Symp Biocomput. 2004;:17-28.
Kim K, Zakharkin SO, Loraine A & Allison DB. Picking the most likely candidates for further development: Novel intersection-union tests for addressing multi-component hypotheses in comparative genomics. Proceedings of the American Statistical Association Joint Statistical Meeting, ENAR Section [CD-ROM], Toronto, Ontario, Canada, Aug 8 - 12, 2004.
Loraine AE, Helt GA, Cline MS, Siani-Rose MA. Exploring alternative transcript structure in the human genome using blocks and InterPro. J Bioinform Comput Biol. 2003 Jul;1(2):289-306.
|
|
|
Labs:
Bioinformatics Research Center
|
|
|
Research Areas:
Bioinformatics
|
|
|
|
