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faculty profile |
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Research Description:
The long-term goal of my research is to determine the initial events that promote genome instability and hematopoietic malignancies. To complement genetic models in the lab, we have several ongoing microarray projects aimed at (1) determining the transcriptional response of hematopoietic cells to DNA damaging agents and environmental toxins, and (2) identifying new biomarkers and prognostic indicators in specific leukemia and lymphoma patient sub-populations. |
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Recent Publications:
P.A. Sung, J. Libura, C. Richardson (2006). Etoposide and illegitimate DNA double-strand break repair in the generation of MLL chromosomal translocations. DNA Repair, 5:1109-1118.
S. Mantha, M. Ward, J. McCafferty, A. Herron, T. Palomero, A. Ferrando, A. Bank, C. Richardson (2006). Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice. Leukemia Research, epub ahead of print.
A.H. Angevine, J.W. McCafferty, G. Bhagat, R.A. Friedman, S.M. Vogel, A. Bank, C. Richardson, J.G. Mears (2006). Differential Gene Expression in Nodular Sclerosis Hodgkins Lymphoma: Revealing the Role of Cells in the Microenvironment in Disease Pathogenesis. Blood, in press.
C. Richardson (2005). Rad51, genomic stability, and tumorigenesis. Cancer Letters, 218:127-139.
J. Libura, D.J. Slater, C.A. Felix, C. Richardson (2005). t-AML-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion. Blood, 105(5):2124-2131.
B. Elliott, C. Richardson, M. Jasin (2005). Chromosomal translocation mechanisms at intronic alu elements in mammalian cells. Molecular Cell, 17:885-894.
C. Richardson, J. Stark, M. Ommundsen, M. Jasin (2004). Over-expression of Rad51 promotes alternative DSB repair and genome instability. Oncogene, 23(2):546-553.
C. Richardson, M. Jasin (2000). Frequent chromosomal translocations induced by DNA double-strand breaks. Nature, 405:697-700.
C. Richardson, M. Moynahan, M. Jasin (1998). Double-strand break repair by interchromosomal recombination: Suppression of chromosomal translocations. Genes and Development, 12:3831-3842.
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Research Areas:
Chromosomal Translocations
DNA Damage
Genome Instability
Leukemia
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