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faculty profile |
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| Dr. Mark Clemens |
| Professor and Vice Chair for Research |
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Department: Biology |
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Office: Woodward Hall 486A |
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Office Hours: |
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Email: mgclemen@uncc.edu |
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Phone: 704-687-8682 |
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Personal Homepage |
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Research Description:
My primary research focus is in vascular control in the liver relevant to liver disease. Areas related to bioinformatics include analysis of perfusion heterogeneity as a function of inflammatory stress or tumor formation and analysis of randomness characteristics of sentry behavior of natural killer T cells as a function of proximity to metastatic tumor target cells. |
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Recent Publications:
W.S. Kamoun, A. Karaa, N. Kresge, S. Merkel, K. Korneszczuk, M.G. Clemens (2006). LPS Inhibits Endothelin-1 Induced Endothelial Nitric Oxide Synthase Activation through a Negative Feedback Involving Caveolin-1. Hepatology, 43(1):182-90.
S. Keller, A. Karaa, M. Paxian, M.G. Clemens, J. Zhang (2006). Inhibition of Endothelin-1 Mediated Upregulation of iNOS by Bosentan Ameliorates Endotoxin-Induced Liver Injury in Cirrhosis. Shock, 25(3):306-13.
Y.S. Zinchenko, L.W. Schrum, M.G. Clemens, R.N. Coger (2006). Hepatocyte and kupffer cells co-cultured on micropatterned surfaces to optimize hepatocyte function. Tissue Engineering, 12(4):751-61.
S.M. Merkel, W. Kamoun, A. Karaa, K. Korneszczuk, L.W. Schrum, M.G. Clemens (2005). LPS Inhibits Endothelin-1-Mediated eNOS Translocation to the Cell Membrane in Sinusoidal Endothelial Cells. Microcirculation, 12:433-442.
W.S Kamoun, Shin MC, Karaa A, M.G. Clemens (2005). Quantification of hepatic microcirculation heterogeneity of perfusion: Effects of endothelin-1. Microvascular Research, 69(3):180-6.
A. Karaa, W. Kamoun, M.G. Clemens (2005). Oxidative stress disrupts nitric oxide synthase activation in liver endothelial cells. Free Radical Biology and Medicine, 39(10):1320-31.
W.S Kamoun, M.C. Shin, S. Keller, A. Karaa, T. Huynh, M.G. Clemens (2005). Induction of Biphasic Changes in Perfusion Heterogeneity of Rat Liver Following Sequential Stress in Vivo. Shock, 24(4):324-331.
A. Karaa, W.S. Kamoun, M.G. Clemens (2005). Chronic Ethanol Sensitizes the Liver to Endotoxin via Effects on Endothelial Nitric Oxide Synthase Regulation. Shock, 24(5):447-54.
M. Paxian, S. Keller, R. Baveja, K. Korneszczuk, T. Huynh, G.M. Clemens (2004). Functional link between ETB receptors and eNOS maintain tissue oxygenation in the normal liver. Microcirculation, 11(5):435-49.
S. Jain, S. Purohit, J. Zhang, M.G. Clemens, C.Y. Lee (2002). Visualization of endothelial cell structure during machine perfusion preservation of livers. Proceedings of IMECE, 1-6.
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Research Areas:
Image Analysis
In-vivo Microscopy
Liver Disease
Microcirculation
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