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faculty profile |
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Research Description:
My research laboratory is currently interested in signal transduction pathways involved in regulating initial cell transformation and progression of hepatocellular carcinoma. Specifically, our studies are interested in how changes in cell signal processing affect the normal cells ability to perform physiological functions in the liver and how these changes (transformation) may affect the rate at which proliferation progresses and/or the resistance of these “damaged” cells to normal mechanisms that delete abnormal cells. In addition, our laboratory is interested in the mechanisms by which alcohol may affect the rate of cell transformation and the potential for plant derived antioxidants as possible agents for use in reducing this risk. In addition, my laboratory is investigating the use of cell encapsulation technology to deliver high circulating cytokine levels in models of HCC as a mechanism to potentially slow tumor progression. |
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Recent Publications:
Moran, D, Mattocks, AM, Cahill, PA, Koniaris, LG & McKillop, IH (2007). Interleukin-6 (IL-6) mediates G0/G1 growth arrest in hepatocellular carcinoma through a STAT3 dependent mechanism. IJ. Surg Res., In press
McKillop, IH and Schrum, LW (2007). Hepatic alcohol metabolism. Encyclopedia of Cancer – 2nd Edition. Ed. Schwab, M. Springer, In Press.
Jablonski, EM, Mattocks, AM, Sokolov, E, Koniaris, LG, Hughes, FM, Fausto, N, Pierce, RH & McKillop, IH (2007). Decreased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinoma. Cancer Letters 250(1):36-46
Moran, DM, Koniaris, LG, Jablonski, EM, Cahill, PA, Halberstadt, CR & McKillop, IH. (2006) Microencapsulation of engineered cells to deliver sustained high circulating levels of interleukin-6 to study hepatocellular carcinoma progression. Cell Transplantation, 15: 785-798
McKillop, IH, Moran, DM, Jin, X, Koniaris, LG. Molecular Pathogenesis of hepatocellular carcinoma. Journal of Surgery Research, 136(1):125-35.
Dréau, D, Karaa, A, Culberson, C, Wyan, H, McKillop, IH, Clemens, MG (2006). Vascular changes associated with the development of bone metastases in an immunocompetent model of mouse mammary carcinoma. Clin Exp Metastasis, 23(1): 41-53.
Kovach, SJ, Price, JA, Theodorakis, NG, Sitzmann, JV, McKillop, IH (2006). Role of cyclic AMP responsive elements (CRE’s) in cell proliferation in a rat model of hepatocellular carcinoma (HCC). Journal of Cellular Physiology, 206(2):411-419.
McKillop, IH, Schrum, LW (2005). Alcohol and liver cancer. Alcohol, 35:195-203.
Moran, D, Mayes, N, Koniaris, LG, Cahill, PA, McKillop, IH (2005). Interlukin-6 inhibits cell proliferation in a rat model of hepatocellular carcinoma. Liver Intl, 25(2):445-457.
Zimmers, TA, McKillop, IH, Pierce, R, Yoo, J-Y, Murtha-Riel, P, Koniaris, LG (2003). Resolving the role of Il-6 in liver regeneration. Hepatology, 38(6):1590-1591.
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Research Areas:
Apoptosis
Hepatocellular Carcinoma
Mitogenesis
Signal Transduction
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