faculty staff graduate students faculty profile Joanna Krueger Associate Professor Department: Chemistry Office: Burson 262 Office Hours: Email: jkkruege@uncc.edu Phone: 704-687-4913 Personal Homepage Research Description: My lab visualizes biomolecular interactions through molecular modeling of small-angle X-ray and neutron solution scattering data with interpretation supported by an integration of numerous structural biology tools- such as selected-site mutagenesis, chemical cross-linking with peptide mapping, spectroscopy (FTIR, CD, UV-VIS, FRET, MS) and available high resolution crystal and/or NMR structure information. Recent Publications: J.K. Gautam, Ashish, L.D. Comeau, J.K. Krueger, M.F. Smith Jr. (2006). Structural and Functional Evidence for the role of the TLR2 DD loop in TLR1/TLR2 Heterodimerization and Signaling. Journal of Biological Chemistry, In press. Ashish, R. Garg, J. Anguita, J.K. Krueger (2006). Binding of Full-length HIV-1 gp120 to CD4 Induces Structural Reorientation Around the gp120 Core. Biophysical Journal, In press J.K. Krueger, G.D. Wignall (2004). Small Angle Neutron Scattering from Biological Molecules. In Neutrons in Biology - Techniques and Applications. (J. Fitter, T. Gutberlet, J. Katsaras, Eds.) Springer Publications Biophysical Studies Series. T.W. Heller, J.K. Krueger, J. Trewhella (2003). Further Insights into Calmodulin-Myosin Light Chain Kinase Interaction from Solution Scattering and Shape Restoration. Biochemistry, 42(36):10579-588. J. Trewhella, J.K. Krueger (2001). Small-angle Solution Scattering Reveals Information on Conformational Dynamics in Calcium Binding Proteins and in Their Interactions with Regulatory Targets. In Methods of Molecular Biology. (H.J. Vogel, Ed.) Vol 173, pp. 137 – 160. Humana Press. J.K. Krueger, S.C. Gallagher, G. Zhi, R. Geguchadze, A. Persechini, J. Stull, J. Trewhella (2001, accelerated publication). Activation of Myosin Light Chain Kinase Requires Translocation of Bound Calmodulin. Journal of Biological Chemistry, 276(7):4535-4538. J.K. Krueger, S.C. Gallagher, A. Wang, J. Trewhella (2000). Calmodulin Remains Extended upon Binding to Smooth Muscle Caldesmon: A Combined Small-Angle Scattering and Fourier Transform Infrared Spectroscopy Study. Biochemistry, 39(14):3979-3987. J. Krueger, B. McCrary, A.H.-J. Wang, J.W. Shriver, J. Trewhella, S.P. Edmondson (1999). Solution Structure of Sac7d/DNA Complex Studied by Small-Angle X-ray Scattering. Biochemistry, 38(32):10247-10255. J. Trewhella, S.C. Gallagher, J.K. Krueger, J. Zhao (1998). Neutron and X-ray Solution Scattering Provide Insights into Biomolecular Structure and Function. Science Progress, 81(2):101-122. J.K. Krueger, G. Zhi, J.T. Stull, J. Trewhella (1998). Neutron Scattering Studies Reveal Further Details of the Ca2+/Calmodulin-Dependent Activation Mechanism of Myosin Light Chain Kinase. Biochemistry, 37(40):13997-14004. Research Areas: Biophysical Chemistry Chemical Cross-Linking with Peptide Mapping Molecular (Protein) Modeling Small-Angle X-ray and Neutron Solution Scattering Spectroscopy (FTIR, CD, UV-VIS, FRET, MS) Copyright © 2009 CCI UNCC